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Pathway scientist helps discover gene crucial to lung and brain development

Pathway Genomics — Fri, 13 Jan 2012 15:51:54 +0000

Scientists at the Salk Institute for Biological Studies have discovered a gene that plays a critical role in the development of multiple cilia, microscopic hair-like structures that propel fluids through the brain and lungs. “Cells with multiple cilia play a number of important roles, including moving fluids through the respiratory tract, brain and spinal cord,” said lead researcher and Salk professor Christopher R. Kintner.

Kintner and his colleague, Pathway Genomics scientist Jennifer Stubbs, made the discovery by analyzing the embryos of Xenopus laevis, commonly known as the African clawed frog, while Stubbs was a postdoctoral fellow in Kintner’s lab. Read more about this exciting discovery…

BlogWatch: “Food Renegade” interviews author of “Deep Nutrition: Why Your Genes Need Traditional Food”

Pathway Genomics — Thu, 05 Jan 2012 02:25:10 +0000

Nutrition and wellness coach Kristen Michaelis, writer and editor of the popular blog Food Renegade, had the opportunity to discuss the topic of genetics, and its relation to nutritional science. In specific, she addresses the topic of epigenetics, which she describes as “the study of how inherited genes are turned on and turned off.” In her article, Michaelis interviews Catherine Shanahan, M.D., author of Deep Nutrition: Why Your Genes Need Traditional Food, which dives deeply into the subject.

“I started writing when I became overwhelmed by the amount of medical research that did nothing to explain chronic illnesses, or what to do to actually cure them. I wanted the world to know that there was research to support eating a traditional diet, tons of it,” Dr. Shanahan explains. “…I wanted to incorporate all the amazing things about the inner workings of the human body that could be brought together to tell the story of health and disease simply by understanding how food affects our body at a cellular, even molecular, level.” Read more about this story…

Diagnosing certain diseases, there (might) be an app for that!

Pathway Genomics — Sat, 24 Dec 2011 01:27:41 +0000

Would you spit on your iPhone? Researchers at the Korea Advanced Institute for Science and Technology are currently developing a way to quickly diagnose specific diseases – with an iPhone and saliva. The researchers claim that the touch sensitivity of smartphones with touch screens – such as the iPhone – might have the capability to be used as a diagnostic chip. According to an article in Forbes, the institute’s “innovation harnesses a touchscreen’s ‘capacitive sensitivity,’ its ability to sense a fingertip’s electrical charge. The iPhone touch screen’s sensitivity extends far beyond that needed to sense a finger touch or tap, leading researchers to speculate what else it could detect, such biomarkers in bodily fluids signifying the presence of disease.” Read more about this story…

BlogWatch: Genomes Unzipped authors challenge recent study connecting genetics and empathy

Pathway Genomics — Fri, 02 Dec 2011 16:50:53 +0000

Last week, DNAction reported on a new study arguing that empathetic character traits, such as being trustworthy and caring, may be powerfully linked to our genetics. The paper was published on November 14 in the Proceedings of the National Academy of Sciences, and the lead author is is Aleksandr Kogan, a postdoctoral fellow at the University of Toronto. Over the last week, there has been some lively discussion about the credibility of the study due to its small population. In an article published in Genomes Unzipped, Joe Pickrell, Jeff Barrett, Daniel MacArthur and Luke Jostins address the problems with the study.

“We find it frustrating to see researchers making two-decade-old mistakes today,” the Genomes Unzipped authors write. “Consider the paper in question by Alex Kogan and colleagues. The authors took a highly-studied candidate gene (the oxytocin receptor) and tested for association between a genetic variant in this gene and a trait called prosociality in a sample of 23 individuals. In light of what we know about complex trait genetics, this study design is hopelessly underpowered.”

Read the full Genomes Unzipped article…

Read a response post by the study’s lead author, Aleksandr Kogan…

Creating the so-called “Google Maps of human disease”

Pathway Genomics — Fri, 11 Nov 2011 02:50:08 +0000

Earlier this month, the U.S. National Research Council called to create a vast network of data combining patients’ routine medical records with leading-edge molecular and genomic data of their diseases. The panel argued that a database of this scope would benefit and improve medical care, and help push it to the next era of “precision medicine.” According to an article in ScienceInsider by Jocelyn Kaiser, and outlined in the panel’s 108-page report, Toward Precision Medicine: Building a Knowledge Network for Biomedical Research and a New Taxonomy of Disease, America needs a “live network of data on individuals’ molecular tests and health records,” and “this system would be used to develop a new disease taxonomy and personalize medical care.” Read more…

Recently published paper calls for nutrigenomics research policy changes

Pathway Genomics — Wed, 09 Nov 2011 00:42:25 +0000

A paper published last week in the American Journal of Clinical Nutrition calls for changes to policy regulating nutrigenomics research. According to the paper “Coevolution of nutrigenomics and society: ethical considerations” by Michiel Korthals of Wageningen University, nutrigenomics research policy should seek to form “a research partnership with society on the basis of fair representation.” Korthals adds that several “normative concepts” associated with nutrigenomics research policy do not align well “with concepts of food and health of various food styles in Western societies.” Read Korthals’ abstract…

The future of genome sequencing a hot topic at ICHG conference in Montreal

Pathway Genomics — Fri, 04 Nov 2011 17:20:10 +0000

As Genomes Unzipped contributing author Luke Jostins writes, the fate of genome sequencing in medicine was a focus of the International Congress of Human Genetics in Montreal. The meeting took place last week, and brought together over 7,000 geneticists. In specific, the highlighted debate, titled “Current and Emerging Sequencing Technologies: Changing the Practice of Medical Genetics,” was especially riveting. Read more at the Genomes Unzipped blog…

Study concludes fear of personal genomics may be an overreaction

Pathway Genomics — Thu, 03 Nov 2011 21:10:33 +0000

Personal genomics has been a controversial topic to the media, medical professionals, policymakers, and the general public. However, according to the findings of a recent study, much of the criticism may be an overreaction. The study, published in the October 2011 issue of Mayo Clinic Proceedings, concludes that there is “little evidence to suggest that predictive genomic risk information consistently influences risk perception or worry in the manner or degree that has been posited by some scientific critics and commentators.” Additionally, the authors suggest that the oversight of genomic technologies on the horizon should be focused on diseases and conditions that have the potential to pose the greatest harm. Read more about this study…

On a related note, the results of this study are similar to the findings of earlier studies showing that disclosure of genetic test results does not lead to increased anxiety. Read more about this…

The Couch Potato Gene

Pathway Genomics — Mon, 31 Oct 2011 23:50:46 +0000

“It could be the perfect excuse for those who find exercise something of a chore: ‘I’m not lazy, it’s my genes.’ Scientists have discovered why some of us have the energy to work out for hours while others can barely summon the get-up-and-go to reach for the TV remote. They believe they have pinpointed the genes that produce an enzyme in our muscles during exercise called AMP kinase, which controls the way we turn food into energy. Those who generate large quantities of AMPK have more energy, whereas those with lesser amounts are likely to tire almost immediately. Dr Gregory Steinberg, who led the research, said the discovery could lead to treatments for those who find it difficult to exercise, including the obese and those with asthma. His team found dramatic results in tests on two groups of mice, one bred without the two suspected genes behind AMPK production.” – from “Gene that makes you a couch potato: Scientists discover why some people have all the energy… and others don’t” by Tamara Cohen, Mail Online. Read more…

If you’re interested in this article, you might also be interested in the DNAction blog post, “The Genetic Connection: Athletic Performance” by contributing author and Pathway scientist Dan Zhu.

Notes from the Conference Trail | San Diego, California | 2011 American Dietetic Association Conference

Pathway Genomics — Thu, 29 Sep 2011 01:48:03 +0000

Michael Nova, M.D., Pathway Genomics’ chief medical officer, presented this week at the 2011 American Dietetic Association (ADA) Food and Nutrition Conference and Expo (FNCE). Dr. Nova’s presentation elaborated on the connections between nutrition, lifestyle and genetic expression.

“Ultimately, people need to know genetic makeup and lifestyle have the power to impact health and wellness,” said Nova. “Pathway’s goal is to educate and empower health care practitioners and patients through detailed personal genetic reports and individualized lifestyle recommendations.”

Ultimately, people need to know genetic makeup and lifestyle have the power to impact health and wellness,” said Nova. “Pathway’s goal is to educate and empower health care practitioners and patients through detailed personal genetic reports and individualized lifestyle recommendations.”

Held at the San Diego Convention Center, the ADA’s annual meeting brought together more than 10,000 registered dietitians, nutrition science researchers, health care providers, industry leaders and policy makers in an effort to address key issues affecting the health of the American people. Tackling the obesity epidemic was a clear highlight of the meeting.